exCel Cosmeceuticals, Inc., has been awarded a full U.S. Patent for
AFAs # 6,197,317 and # 6,703,030, with other patents still pending.
AFA gels are powerful yet gentle antioxidants that are based
on the use of the same Amino Acids that result from the proteolysis
of Filaggrin in human skin. Filaggrin functions in human skin as a
filament aggregator in the epidermis. After its structural role is
completed it is proteolyzed into acidic amino acids that accumulate
in the stratum Granulosum where they serve as the main moisture retention
factor of the epidermis.
AFAs is an acronym for Antioxidant Filaggrin based Amino acids.
exCels Patent covers the use of any or all of the acidified
amino acids at a wide range of pHs. It is interesting to note that
several of the Amino acid s that result from the proteolysis of Filaggrin
are, with the exception of the amino group, (NH3), molecularly identical
to certain AHA molecules. When the Amino Acids are prepared at a suitably
low pH, they are effectively hyper-carboxylated; that is, the additional
carboxyl groups that are part of the amino acid molecule become effective
as anti-oxidants, (It is the Hydrogen Ion of the Carboxyl-COOH-moiety
that is believed to serve as the proton donating entity.)
AFA gels have been clinically tested for three years by independent
board-certified dermatologists and have been found to be rapidly effective
in reducing the appearance of visible lines and improving the tone
and texture of the skin. They are also extremely effective in reducing
photo-pigmentation. Also, AFAs are unique in that they can function
at very low pHs without any of the irritation associated with those
pH levels that is found in other commercially available products.
Marvin E. Klein, M.D., the inventor of AFAs, a board certified
dermatologist and recipient of the National American Dermatology Association
Research Award, was a member of Galens Honorary Medical Society.
Dr. Marvin E. Klein gained international recognition for his proprietary
formulations, including an esterified glycolic acid (AHA) and a trichloroacetic
acid (TCA) masque (Accupeel ®). The company he created to distribute
these products, Glyderm, has since been sold to an international pharmaceutical
company and the products continue to be successfully distributed worldwide.